P4hb^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: P4hb^tm1.2Geno
• Name: prolyl 4-hydroxylase, beta polypeptide; targeted mutation 1.2, Genoway
• MGI ID: MGI:5504625
• Synonyms: PDI^-
• Gene: P4hb Location: Chr11:120451124-120464079 bp, - strand Genetic Position: Chr11, 84.27 cM, cytoband D-E
• Alliance: P4hb^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197556
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3'loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 1 and 2 floxed. Cre-mediated recombination removed exons 1 and 2. (J:197556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P4hb Mutation: 32 strains or lines available

References

• Original: J:197556 Hahm E, et al., Extracellular protein disulfide isomerase regulates ligand-binding activity of alphaMbeta2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013 May 9;121(19):3789-800, S1-15
• All: 2 reference(s)