Serpinh1^tm2Kzn
Targeted Allele Detail

Summary

• Symbol: Serpinh1^tm2Kzn
• Name: serine (or cysteine) peptidase inhibitor, clade H, member 1; targeted mutation 2, Kazuhiro Nagata
• MGI ID: MGI:5505265
• Synonyms: Hsp47^flox
• Gene: Serpinh1 Location: Chr7:98994583-99002321 bp, - strand Genetic Position: Chr7, 54.07 cM
• Alliance: Serpinh1^tm2Kzn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197791
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neo cassette with a 3'loxP site was inserted downstream of exon 6. (J:197791)

Disease models

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Serpinh1 Mutation: 59 strains or lines available

References

• Original: J:197791 Masago Y, et al., The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation. J Cell Sci. 2012 Mar 1;125(Pt 5):1118-28
• All: 6 reference(s)