Mad2l2^tm1Ymu
Targeted Allele Detail

Summary

• Symbol: Mad2l2^tm1Ymu
• Name: MAD2 mitotic arrest deficient-like 2; targeted mutation 1, Yoshiki Murakumo
• MGI ID: MGI:5505390
• Synonyms: Rev7^-
• Gene: Mad2l2 Location: Chr4:148214841-148230156 bp, + strand Genetic Position: Chr4, 78.67 cM, cytoband E1
• Alliance: Mad2l2^tm1Ymu page

Growth retardation and small testis in Mad2l2^tm1Ymu/Mad2l2^tm1Ymu mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced part of exon 1 and exon 2. Western blot analysis confirmed the absence of protein expression the testis, kidney, liver and spleen. (J:198275)

Generation of the Mad2l2^tm1Ymu allele

Expression

In Mice Carrying this Mutation:	54 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mad2l2 Mutation: 15 strains or lines available

References

• Original: J:198275 Watanabe N, et al., The REV7 subunit of DNA polymerase zeta is essential for primordial germ cell maintenance in the mouse. J Biol Chem. 2013 Apr 12;288(15):10459-71
• All: 1 reference(s)