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Arhgef11tm1Sgkd
Targeted Allele Detail
Summary
Symbol: Arhgef11tm1Sgkd
Name: Rho guanine nucleotide exchange factor 11; targeted mutation 1, Silvio Gutkind
MGI ID: MGI:5505410
Synonyms: Prg-
Gene: Arhgef11  Location: Chr3:87524866-87645341 bp, + strand  Genetic Position: Chr3, 38.22 cM
Alliance: Arhgef11tm1Sgkd page
Arhgef11tm1Sgkd/Arhgef11tm1Sgkd Arhgef12tm1Sgkd/Arhgef12tm1Sgkd embryos are less developed with partial branching failure of the cranial vessels

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198274
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2 and 3. Western blot analysis confirmed the absence of protein expression in the cerebellum. (J:198274)
Generation of the Arhgef11tm1Sgkd allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 23 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef11 Mutation:  77 strains or lines available
References
Original:  J:198274 Mikelis CM, et al., PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem. 2013 Apr 26;288(17):12232-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory