Reln^ctrdel
Chemically induced Allele Detail

Summary

• Symbol: Reln^ctrdel
• Name: reelin; C-terminal deletion
• MGI ID: MGI:5505412
• Synonyms: line 13, Reln^CTRdel
• Gene: Reln Location: Chr5:22089452-22549700 bp, - strand Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
• Alliance: Reln^ctrdel page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Eight week old A/J male mice were treated weekly for three weeks with ENU. After several weeks of recovery, mice were crossed to C57BL/6 females with or without a lacZ reporter. Resulting females were backrossed to their fathers and subjected to phenotype screening. A 42 bp insertion was found after exon 63 due to a T to C mutation at the exon 63 distal splice junction. Five amino acids and a stop codon were added and the 33 terminal amino acids were lost. (J:199782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Reln Mutation: 209 strains or lines available

References

• Original: J:199782 Ha S, et al., A forward genetic screen in mice identifies mutants with abnormal cortical patterning. Cereb Cortex. 2015 Jan;25(1):167-79
• All: 3 reference(s)