Dnaaf1^m4Bei
Chemically induced Allele Detail

Summary

• Symbol: Dnaaf1^m4Bei
• Name: dynein, axonemal assembly factor 1; mutation 4, David R Beier
• MGI ID: MGI:5505439
• Synonyms: line 42
• Gene: Dnaaf1 Location: Chr8:120301974-120325193 bp, + strand Genetic Position: Chr8, 67.98 cM, cytoband E1
• Alliance: Dnaaf1^m4Bei page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: The molecular lesion is in Dnaaf1 (NM_026648) at chr8:119582732 bp (exon 4: c.556 + 2T - C). This is in the splice donor site of exon 4, two bases distal from the exon. This results in splicing mutations, with both skipping of exon 4 and retention of intron 4 seen in RT-PCR analysis. Either splicing mutation will result in premature truncation of the encoded protein. (J:199782, J:240195)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnaaf1 Mutation: 32 strains or lines available

References

• Original: J:199782 Ha S, et al., A forward genetic screen in mice identifies mutants with abnormal cortical patterning. Cereb Cortex. 2015 Jan;25(1):167-79
• All: 2 reference(s)