Drc3^m6Bei
Chemically induced Allele Detail

Summary

• Symbol: Drc3^m6Bei
• Name: dynein regulatory complex subunit 3; mutation 6, David R Beier
• MGI ID: MGI:5505445
• Synonyms: line 67, Lrrc48^m6Bei
• Gene: Drc3 Location: Chr11:60244155-60285167 bp, + strand Genetic Position: Chr11, 37.81 cM, cytoband B2
• Alliance: Drc3^m6Bei page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The molecular lesion in Lrrc48 (NM_029044) is located at Chr11:60363569 bp (exon4: c.T266C: p.L89P). This is a missense mutation that substitutes proline for leucine. qRT-RCR analysis using primers for exon 89 confirmed a reduction of gene expression in the mutant to 34% of wild-type levels (P greater than 0.001). (J:199782, J:240195)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drc3 Mutation: 25 strains or lines available

References

• Original: J:199782 Ha S, et al., A forward genetic screen in mice identifies mutants with abnormal cortical patterning. Cereb Cortex. 2015 Jan;25(1):167-79
• All: 2 reference(s)