Rtel1^tm2.1Pml
Targeted Allele Detail

Summary

• Symbol: Rtel1^tm2.1Pml
• Name: regulator of telomere elongation helicase 1; targeted mutation 2.1, Peter M Lansdorp
• MGI ID: MGI:5505465
• Synonyms: mRtel1^tag
• Gene: Rtel1 Location: Chr2:180961532-180998409 bp, + strand Genetic Position: Chr2, 103.63 cM
• Alliance: Rtel1^tm2.1Pml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197762
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: Epitope and fluorescent tags (FlexLink-6xHis-TEVcs-Venus-3xFLAG) were inserted into the 3' end of exon 34 just upstream of the termination site. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the 3'UTR. (J:197762)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtel1 Mutation: 75 strains or lines available

References

• Original: J:197762 Uringa EJ, et al., RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell. 2012 Jul;23(14):2782-92
• All: 1 reference(s)