Tle3^tm1.1Pton
Targeted Allele Detail

Summary

• Symbol: Tle3^tm1.1Pton
• Name: transducin-like enhancer of split 3; targeted mutation 1.1, Peter Tontonoz
• MGI ID: MGI:5505553
• Synonyms: TLE3^F
• Gene: Tle3 Location: Chr9:61279665-61325772 bp, + strand Genetic Position: Chr9, 33.27 cM, cytoband C
• Alliance: Tle3^tm1.1Pton page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198134
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A gene trap cassette containing a beta-geo reporter with a 5' FRT site was inserted upstream of exon 3. An additional FRT site was inserted downstream of exon 3. Flp-mediated recombination removed the gene trap cassette and left exon 3 floxed. (J:198134)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tle3 Mutation: 47 strains or lines available

References

• Original: J:198134 Villanueva CJ, et al., Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARgamma specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 5;17(3):423-35
• All: 3 reference(s)