Epg5^tm1Ygz
Targeted Allele Detail

Summary

• Symbol: Epg5^tm1Ygz
• Name: ectopic P-granules 5 autophagy tethering factor; targeted mutation 1, Yan G Zhao
• MGI ID: MGI:5505596
• Gene: Epg5 Location: Chr18:77981680-78078228 bp, + strand Genetic Position: Chr18, 52.38 cM
• Alliance: Epg5^tm1Ygz page

Epg5^tm1Ygz/Epg5^tm1Ygz mice show motor deficits

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196603
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced exons 18 and 19. Western blot analysis confirmed the absence of protein expression. (J:196603)

Generation of the Epg5^tm1Ygz allele

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epg5 Mutation: 106 strains or lines available

References

• Original: J:196603 Zhao H, et al., Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration. J Cell Biol. 2013 Mar 18;200(6):731-41
• All: 6 reference(s)