Ephb1^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Ephb1^tm1.1Meg
• Name: Eph receptor B1; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:5505686
• Synonyms: EphB1^T697G
• Gene: Ephb1 Location: Chr9:101799327-102231892 bp, - strand Genetic Position: Chr9, 54.15 cM
• Alliance: Ephb1^tm1.1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197489
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutation: Single point mutation
• Mutation details: Nucleotide substitution (T to G) in exon 11 results in the amino acid substitution of threonine with glycine at position 679 (p.T697G) in the encoded protein. This mutation creates a PP1 analog-sensitive protein. Cre-mediated recombination removed the loxP site flanked neomycin resistance gene cassette inserted into intron 11. (J:197489)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephb1 Mutation: 43 strains or lines available

References

• Original: J:197489 Soskis MJ, et al., A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. 2012 Dec;15(12):1645-54
• All: 2 reference(s)