Grin2b^tm1.1Nhk
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1.1Nhk
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1.1, Noboru H Komiyama
• MGI ID: MGI:5505780
• Synonyms: GluN2B^2A(CTR)
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1.1Nhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197485
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 12 was replaced with the corresponding exon 12 from Grin2a and a floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. (J:197485)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 99 strains or lines available

References

• Original: J:197485 Ryan TJ, et al., Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Nat Neurosci. 2013 Jan;16(1):25-32
• All: 3 reference(s)