Runx3^{tm1.1(cre/ERT2)Tmj}
Targeted Allele Detail

Summary

• Symbol: Runx3^{tm1.1(cre/ERT2)Tmj}
• Name: runt related transcription factor 3; targeted mutation 1.1, Thomas M Jessell
• MGI ID: MGI:5505843
• Synonyms: Rx3:Cre^ER
• Gene: Runx3 Location: Chr4:134847963-134905301 bp, + strand Genetic Position: Chr4, 67.19 cM
• Alliance: Runx3^{tm1.1(cre/ERT2)Tmj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Runx3^{tm1.1(cre/ERT2)Tmj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Runx3 (MGI:102672)

• Mutation details: An IRES-cre/ERT2-Frt-PGKneo-Frt cassette was inserted into the Runx3 gene just downstream of the stop codon in exon 6. Germline mutants were crossed to Flp expressing mice to remove the neo marker. (J:197913)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Runx3 (mouse) Summary of all recombinase alleles driven by Runx3. Alliance mouse Runx3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx3 Mutation: 27 strains or lines available

References

• Original: J:197913 de Nooij JC, et al., Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets. Neuron. 2013 Mar 20;77(6):1055-68
• All: 1 reference(s)