Khdrbs3^tm1.2Dell
Targeted Allele Detail

Summary

• Symbol: Khdrbs3^tm1.2Dell
• Name: KH domain containing, RNA binding, signal transduction associated 3; targeted mutation 1.2, David J Elliott
• MGI ID: MGI:5505896
• Gene: Khdrbs3 Location: Chr15:68800269-68973060 bp, + strand Genetic Position: Chr15, 30.36 cM
• Alliance: Khdrbs3^tm1.2Dell page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199861
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT flanked neo cassette was inserted downstream of exon 2. Both the selection cassette and exon 2 were also flanked by loxP sites. Flp recombinase was used to excise the selection cassette from properly targeted mice. Exon 2 was then removed by cre expression leading to a truncated mRNA as detected by RT-PCR. No protein was detected by Western blot analysis. (J:199861)

Generation of the Khdrbs3^tm1.1Dell (C) and Khdrbs3^tm1.2Dell (D) alleles

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Khdrbs3 Mutation: 26 strains or lines available

References

• Original: J:199861 Ehrmann I, et al., The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain. PLoS Genet. 2013 Apr;9(4):e1003474
• All: 4 reference(s)