Krt19^{tm1(cre/ERT2)Szki}
Targeted Allele Detail

Summary

• Symbol: Krt19^{tm1(cre/ERT2)Szki}
• Name: keratin 19; targeted mutation 1, Atsushi Suzuki
• MGI ID: MGI:5506739
• Synonyms: CK19-CreER^T2
• Gene: Krt19 Location: Chr11:100031636-100036752 bp, - strand Genetic Position: Chr11, 63.42 cM
• Alliance: Krt19^{tm1(cre/ERT2)Szki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192740
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Krt19^{tm1(cre/ERT2)Szki} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt19 (MGI:96693)

• Mutation details: A cre/ERT2 cassette was inserted into exon 1 of the Krt19 gene by homologous recombination in ES cells. (J:192740)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt19 (mouse) Summary of all recombinase alleles driven by Krt19. Alliance mouse Krt19 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt19 Mutation: 21 strains or lines available

References

• Original: J:192740 Sekiya S, et al., Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest. 2012 Nov 1;122(11):3914-8
• All: 2 reference(s)