Scn8a^m10J
Spontaneous Allele Detail

Summary

• Symbol: Scn8a^m10J
• Name: sodium channel, voltage-gated, type VIII, alpha; mutation 10 Jackson
• MGI ID: MGI:5506774
• Gene: Scn8a Location: Chr15:100767739-100943819 bp, + strand Genetic Position: Chr15, 56.39 cM, cytoband F1
• Alliance: Scn8a^m10J page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This spontaneous C-to-A transversion in chromosome 15 nucleotide 101,013,440 (GRCm38) causes an arginine to serine substitution at amino acid 914 (p.R914S), which is in the ion pore region of domain 2. (J:199990)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn8a Mutation: 99 strains or lines available

References

• Original: J:199990 Schroeder DG, et al., The Scn8a^m10J spontaneous point mutation. MGI Direct Data Submission. 2013
• All: 2 reference(s)