Ccl2^tm1.2Tyos
Targeted Allele Detail

Summary

• Symbol: Ccl2^tm1.2Tyos
• Name: C-C motif chemokine ligand 2; targeted mutation 1.2, Teizo Yoshimura
• MGI ID: MGI:5507824
• Synonyms: MCP-1^flox
• Gene: Ccl2 Location: Chr11:81926403-81928278 bp, + strand Genetic Position: Chr11, 49.82 cM, cytoband C-E1
• Alliance: Ccl2^tm1.2Tyos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151874
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Mice containing the floxed Ccl2^tm1Tyos allele were crossed with EIIa-Cre mice to remove the floxed neo cassette. These mice retain exons 1 and 2 flanked by loxP sites. (J:151874)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl2 Mutation: 25 strains or lines available

References

• Original: J:151874 Takahashi M, et al., Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J Immunol. 2009 Sep 1;183(5):3463-71
• All: 4 reference(s)