Rab36^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rab36^{tm1b(KOMP)Wtsi}
• Name: RAB36, member RAS oncogene family; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5507834
• Gene: Rab36 Location: Chr10:74872890-74890580 bp, + strand Genetic Position: Chr10, 38.49 cM, cytoband B5.3
• Alliance: Rab36^{tm1b(KOMP)Wtsi} page
• IMPC: Rab36 gene page

Mutation origin

• Mutant Cell Line: EPD0107_5_F04
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 74877240 of Chromosome 10 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of the targeted exon(s) at position 74878046. The critical exon(s) were thus flanked by loxP sites, and subsequent Cre-mediated excision deleted the essential sequence along with the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:148605, J:173534, J:188991)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab36 Mutation: 26 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 7 reference(s)