Kdm6a^{tm1b(EUCOMM)Jae}
Targeted Allele Detail

Summary

• Symbol: Kdm6a^{tm1b(EUCOMM)Jae}
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1b, Rudolf Jaenisch
• MGI ID: MGI:5507843
• Synonyms: Utx^ko
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^{tm1b(EUCOMM)Jae} page
• IMPC: Kdm6a gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188485
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was obtained from the European knockout consortium (EUCOMM). The targeting construct contains a splice acceptor, beta-geo cassette flanked by two Flp sites preceding the third exon. In addition, the targeting construct introduced two loxP sites on either side of exon 3. Transient cre expression resulted in the excision of exon 3 while leaving the FRT flanked beta-geo intact. (J:188485)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 40 strains or lines available

References

• Original: J:188485 Welstead GG, et al., X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13004-9
• All: 2 reference(s)