Tg(Thy1-VCP*A232E)BMaki
Transgene Detail

Summary

• Symbol: Tg(Thy1-VCP*A232E)BMaki
• Name: transgene insertion B, Masashi Kitazawa
• MGI ID: MGI:5508556
• Transgene: Tg(Thy1-VCP*A232E)BMaki Location: unknown
• Alliance: Tg(Thy1-VCP*A232E)BMaki page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-VCP*A232E)BMaki expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VCP (7415)

  Vcp	(MGI:99919)

• Mutation details: This transgenic construct contains human VCP with the disease-relevant A232E mutation under the control of the forebrain specific Thy1 (Thy1.2) promoter. Two lines were established, A and B. Line B contains 3-4x more copies of the transgene than line A. (J:199083)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:199083 Rodriguez-Ortiz CJ, et al., Neuronal-Specific Overexpression of a Mutant Valosin-Containing Protein Associated with IBMPFD Promotes Aberrant Ubiquitin and TDP-43 Accumulation and Cognitive Dysfunction in Transgenic Mice. Am J Pathol. 2013 Aug;183(2):504-15
• All: 1 reference(s)