Prmt6^tm1.2Rchd
Targeted Allele Detail

Summary

• Symbol: Prmt6^tm1.2Rchd
• Name: protein arginine N-methyltransferase 6; targeted mutation 1.2, Stephane Richard
• MGI ID: MGI:5508653
• Gene: Prmt6 Location: Chr3:110153425-110158314 bp, - strand Genetic Position: Chr3, 48.52 cM
• Alliance: Prmt6^tm1.2Rchd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. A loxP- and FRT-flanked neomycin resistance cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. Cre-mediated recombination removed exon 1. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:199753)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prmt6 Mutation: 20 strains or lines available

References

• Original: J:199753 Neault M, et al., Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 2012 Oct;40(19):9513-21
• All: 4 reference(s)