Cgn^tm1.1Citi
Targeted Allele Detail

Summary

• Symbol: Cgn^tm1.1Citi
• Name: cingulin; targeted mutation 1.1, Sandra Citi
• MGI ID: MGI:5508663
• Gene: Cgn Location: Chr3:94667376-94693826 bp, - strand Genetic Position: Chr3, 40.74 cM
• Alliance: Cgn^tm1.1Citi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200284
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 1. The neomycin resistance cassette and exon 1 were removed via Cre-mediated recombination in the germline. Immunohistochemistry confirmed the absence of protein expression in epithelial tissues. (J:200284)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cgn Mutation: 58 strains or lines available

References

• Original: J:200284 Guillemot L, et al., Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci. 2012 Nov 1;125(Pt 21):5005-14
• All: 2 reference(s)