Rc3h1^tm1.2Cgv
Targeted Allele Detail

Summary

• Symbol: Rc3h1^tm1.2Cgv
• Name: RING CCCH (C3H) domains 1; targeted mutation 1.2, Carola Vinuesa
• MGI ID: MGI:5508923
• Synonyms: Rc3h1^rin, ringless
• Gene: Rc3h1 Location: Chr1:160733988-160802548 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Rc3h1^tm1.2Cgv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted flanking exon 2 and an FRT flanked neo cassette was inserted in intron 2. Properly targeted mice were then crossed to mice expressing flp recombinase to remove the selection cassette. Finally, mice were crossed to cre expressing mice to excise exon 2 which contains the RING domain. A smaller, in frame transcript was produced reflecting the absence of the RING domain. (J:196137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rc3h1 Mutation: 42 strains or lines available

References

• Original: J:196137 Pratama A, et al., Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation. Immunity. 2013 Apr 18;38(4):669-80
• All: 2 reference(s)