Pten^tm1Engc
Targeted Allele Detail

Summary

• Symbol: Pten^tm1Engc
• Name: phosphatase and tensin homolog; targeted mutation 1, Charis Eng
• MGI ID: MGI:5509194
• Synonyms: Pten-m3m4, Pten^M3M4
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1Engc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200739
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: CD-1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Five missense mutations were introduced into the nuclear localization sequences 3 and 4 in exon 7 and a neo selection cassette was inserted in intron 7 via homologous recombination. The expressed protein is localized predominantly in the cytoplasm. (J:200739, J:210487)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:200739 Mester JL, et al., Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. Eur J Hum Genet. 2011 Jul;19(7):763-8
• All: 7 reference(s)