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Pip5k1ctm2.1Ref
Targeted Allele Detail
Summary
Symbol: Pip5k1ctm2.1Ref
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 2.1, Reinhard Fassler
MGI ID: MGI:5509203
Synonyms: PIPKIgamma-
Gene: Pip5k1c  Location: Chr10:81128797-81155807 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Pip5k1ctm2.1Ref page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200273
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 18. An additional loxP site was inserted downstream of exon 18. Cre-mediated recombination removed the neomycin resistance cassette and exon 18. Western blot analysis confirmed the absence of protein expression in the brain. (J:200273)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pip5k1c Mutation:  41 strains or lines available
References
Original:  J:200273 Legate KR, et al., Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Igamma in vivo. J Cell Sci. 2012 Dec 1;125(Pt 23):5636-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory