Pip5k1c^tm1.1Ref
Targeted Allele Detail

Summary

• Symbol: Pip5k1c^tm1.1Ref
• Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 1.1, Reinhard Fassler
• MGI ID: MGI:5509207
• Synonyms: PIPKIgammadeltaE17 fl
• Gene: Pip5k1c Location: Chr10:81128797-81155807 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Pip5k1c^tm1.1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180016
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 17. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 17. Flp-mediated recombination removed the neomycin resistance cassette. (J:180016)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pip5k1c Mutation: 41 strains or lines available

References

• Original: J:180016 Legate KR, et al., Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis. EMBO J. 2011 Nov 16;30(22):4539-53
• All: 3 reference(s)