Prx^tm2.1Brp
Targeted Allele Detail

Summary

• Symbol: Prx^tm2.1Brp
• Name: periaxin; targeted mutation 2.1, Peter Brophy
• MGI ID: MGI:5509222
• Synonyms: Prx^fl
• Gene: Prx Location: Chr7:27198730-27219466 bp, + strand Genetic Position: Chr7, 15.91 cM
• Alliance: Prx^tm2.1Brp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199744
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5, which encodes the PDZ domain. A floxed neomycin resistance cassette was inserted downstream of exon 5. Cre-mediated recombination removed the neomycin resistance cassette and left exon 5 floxed. (J:199744)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prx Mutation: 45 strains or lines available

References

• Original: J:199744 Wu LM, et al., Increasing internodal distance in myelinated nerves accelerates nerve conduction to a flat maximum. Curr Biol. 2012 Oct 23;22(20):1957-61
• All: 1 reference(s)