Mmp19^tm1Rase
Targeted Allele Detail

Summary

• Symbol: Mmp19^tm1Rase
• Name: matrix metallopeptidase 19; targeted mutation 1, Radislav Sedlacek
• MGI ID: MGI:5509300
• Gene: Mmp19 Location: Chr10:128626779-128636693 bp, + strand Genetic Position: Chr10, 77.16 cM
• Alliance: Mmp19^tm1Rase page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137128
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The catalytic domain of Mmp19 (1088 bp region spanning the end of exon 3 and whole of exon 4) was replaced with a neoR cassette oriented in the opposite direction to the endogenous Mmp19. Immunoblotting and immunohistochemistry confirmed absence of MMP19 protein in cell lysates and in skin, respectively. (J:137128)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mmp19 Mutation: 20 strains or lines available

References

• Original: J:137128 Beck IM, et al., MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses. PLoS One. 2008;3(6):e2343
• All: 3 reference(s)