Sox10^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Sox10^M2Btlr
• Name: SRY (sex determining region Y)-box 10; mutation 2, Bruce Beutler
• MGI ID: MGI:5509309
• Synonyms: Kat
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An ENU-induced A to G transition at base pair 79163319 (v38) on chromosome 15, or base pair 1172 in the GenBank genomic region NC_000081 encoding Sox10. The mutation corresponds to residue 685 in the NM_011437.1 mRNA sequence in exon 2 of 4 total exons. The mutation results in a glutamic acid (E) to glycine (G) substitution at residue 133. (J:200817)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:200817 Purrington T, et al., Direct Data Submission for Kat. MGI Direct Data Submission. 2013
• All: 1 reference(s)