Amfr^tm1.1Amw
Targeted Allele Detail

Summary

• Symbol: Amfr^tm1.1Amw
• Name: autocrine motility factor receptor; targeted mutation 1.1, Allan M Weissman
• MGI ID: MGI:5509334
• Synonyms: gp78^-
• Gene: Amfr Location: Chr8:94698216-94739301 bp, - strand Genetic Position: Chr8, 45.96 cM
• Alliance: Amfr^tm1.1Amw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200251
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT and loxP flanked neomycin resistance cassette was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 8. Cre-mediated recombination removed the neomycin resistance cassette, exon 7 and exon 8. Western blot analysis confirmed the absence of protein in mouse embronic fibroblasts. (J:200251)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amfr Mutation: 42 strains or lines available

References

• Original: J:200251 Tsai YC, et al., Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Mol Biol Cell. 2012 Dec;23(23):4484-94
• All: 1 reference(s)