Sytl1^tm1Tiz
Targeted Allele Detail

Summary

• Symbol: Sytl1^tm1Tiz
• Name: synaptotagmin-like 1; targeted mutation 1, Tetsuro Izumi
• MGI ID: MGI:5509384
• Gene: Sytl1 Location: Chr4:132980401-132990398 bp, - strand Genetic Position: Chr4, 66.25 cM
• Alliance: Sytl1^tm1Tiz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200233
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in islets. (J:200233)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sytl1 Mutation: 27 strains or lines available

References

• Original: J:200233 Wang H, et al., The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Mol Biol Cell. 2013 Feb;24(3):319-30
• All: 1 reference(s)