Kittm5.1Bsm
Targeted Allele Detail
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Symbol: |
Kittm5.1Bsm |
Name: |
KIT proto-oncogene receptor tyrosine kinase; targeted mutation 5.1, Peter Besmer |
MGI ID: |
MGI:5510143 |
Synonyms: |
KitV558delta |
Gene: |
Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
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Alliance: |
Kittm5.1Bsm page
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Cecal gastrointestinal stromal tumor and gastric/colonic interstatial cell of Cajal hyperplasia in Kittm5.1Bsm/Kit+ and Kittm4.1Bsm/Kit+ mice
Show the 2 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A single point mutation deleting valine 558 was introduced to exon 11 and a floxed neomycin resistance cassette was introduced to intron 11 via homologous recombination. Cre-mediated recombination removed the neomycin resistance cassette.
(J:188434)
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Generation of the Kittm5.1Bsm allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kit Mutation: |
182 strains or lines available
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Original: |
J:188434 Bosbach B, et al., Imatinib resistance and microcytic erythrocytosis in a KitV558Delta;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2276-83 |
All: |
1 reference(s) |
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