About   Help   FAQ
Kittm5.1Bsm
Targeted Allele Detail
Summary
Symbol: Kittm5.1Bsm
Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 5.1, Peter Besmer
MGI ID: MGI:5510143
Synonyms: KitV558delta
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Kittm5.1Bsm page
Cecal gastrointestinal stromal tumor and gastric/colonic interstatial cell of Cajal hyperplasia in Kittm5.1Bsm/Kit+ and Kittm4.1Bsm/Kit+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188434
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single point mutation deleting valine 558 was introduced to exon 11 and a floxed neomycin resistance cassette was introduced to intron 11 via homologous recombination. Cre-mediated recombination removed the neomycin resistance cassette. (J:188434)
Generation of the Kittm5.1Bsm allele
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  182 strains or lines available
References
Original:  J:188434 Bosbach B, et al., Imatinib resistance and microcytic erythrocytosis in a KitV558Delta;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2276-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory