Selenon^tm1Begg
Targeted Allele Detail

Summary

• Symbol: Selenon^tm1Begg
• Name: selenoprotein N; targeted mutation 1, Alan H Beggs
• MGI ID: MGI:5510170
• Gene: Selenon Location: Chr4:134265203-134279477 bp, - strand Genetic Position: Chr4, 66.85 cM, cytoband D3
• Alliance: Selenon^tm1Begg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197753
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 9 and 114 and 2 bp of intronic regions upstream and downstream of exon 9, respectively. Western blot analysis confirmed the absence of protein expression in lung, diaphragm, heart and quadriceps. (J:197753)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenon Mutation: 26 strains or lines available

References

• Original: J:197753 Moghadaszadeh B, et al., Selenoprotein N deficiency in mice is associated with abnormal lung development. FASEB J. 2013 Apr;27(4):1585-99
• All: 1 reference(s)