Scn1a^tm1Kea
Targeted Allele Detail

Summary

• Symbol: Scn1a^tm1Kea
• Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 1, Jennifer Kearney
• MGI ID: MGI:5510417
• Gene: Scn1a Location: Chr2:66101125-66271181 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn1a^tm1Kea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203040
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance cassette replaced the first coding exon. Absence of protein was confirmed by immunoblotting. (J:203040)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn1a Mutation: 114 strains or lines available

References

• Original: J:203040 Miller AR, et al., Mapping genetic modifiers of survival in a mouse model of Dravet syndrome. Genes Brain Behav. 2014 Feb;13(2):163-72
• All: 49 reference(s)