Psaptm4.1Ggb
Targeted Allele Detail
|
Symbol: |
Psaptm4.1Ggb |
Name: |
prosaposin; targeted mutation 4.1, Gregory A Grabowski |
MGI ID: |
MGI:5510529 |
Synonyms: |
AB- |
Gene: |
Psap Location: Chr10:60113449-60138376 bp, + strand Genetic Position: Chr10, 30.02 cM
|
Alliance: |
Psaptm4.1Ggb page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:198242
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129S/SvEv
|
|
Allele Type: |
|
Targeted |
Mutations: |
|
Insertion, Nucleotide substitutions
|
|
|
Mutation details: Nucleotide substitutions result in the amino acid substitution of Cys 4 of saposins A and B located in exon 4 (saposin A domain) and exon 7 (saposin B domain) with phenylalanine. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon 7. Western blot analysis confirmed the absence of saponin A and B, overexpression of saponin C and normal expression of saponin D in the cerebrum and liver.
(J:198242)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Psap Mutation: |
36 strains or lines available
|
|
Original: |
J:198242 Sun Y, et al., Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum Mol Genet. 2013 Jun 15;22(12):2435-50 |
All: |
1 reference(s) |
|