Clec4g^tm1.1Fhe
Targeted Allele Detail

Summary

• Symbol: Clec4g^tm1.1Fhe
• Name: C-type lectin domain family 4, member g; targeted mutation 1.1, Fuchu He
• MGI ID: MGI:5510586
• Gene: Clec4g Location: Chr8:3757064-3770651 bp, - strand Genetic Position: Chr8, 1.92 cM
• Alliance: Clec4g^tm1.1Fhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200968
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced by a floxed PGK-neomycin selection cassette. The selection cassette was then removed from properly targeted mice by cre excision. Absence of transcription was confirmed by rtPCR and loss of protein by immunofluorescein staining. (J:200968)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec4g Mutation: 29 strains or lines available

References

• Original: J:200968 Tang L, et al., Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response. Gastroenterology. 2009 Oct;137(4):1498-508.e1-5
• All: 5 reference(s)