Crkl^snoopy
Chemically induced Allele Detail

Summary

• Symbol: Crkl^snoopy
• Name: v-crk avian sarcoma virus CT10 oncogene homolog-like; snoopy
• MGI ID: MGI:5510713
• Synonyms: 12WT-9, Crkl^sno
• Gene: Crkl Location: Chr16:17269851-17305298 bp, + strand Genetic Position: Chr16, 10.82 cM
• Alliance: Crkl^snoopy page

Craniofacial and skeletal mutants: (A-D) Fras1^bfb, (E-G) Ift140^cauli, (H-J) knyn, and (K-M) Crkl^snoopy homozygotes

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6JAnu

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a T-to-C substitution in the Crkl gene, at position Chr16:17,452,790 (GRCm38). This nucleotide substitution resides 2 nucleotides downstream of exon 1. The mutant transcript is predicted to result in a loss of a putative splice donor and/or generation of additional exonic splice enhancers. Mutant embryos exhibit a loss of transcript expression compared to controls. Western blot analysis of protein extracted from whole E13.5 embryos confirmed the loss of protein in mutant mice. (J:251775)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crkl Mutation: 17 strains or lines available

References

• Original: J:199856 Caruana G, et al., Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease. PLoS One. 2013;8(3):e55429
• All: 2 reference(s)