Ctdnep1^tm2Ryn
Targeted Allele Detail

Summary

• Symbol: Ctdnep1^tm2Ryn
• Name: CTD nuclear envelope phosphatase 1; targeted mutation 2, Ryuichi Nishinakamura
• MGI ID: MGI:5510831
• Synonyms: Dullard^LacZ
• Gene: Ctdnep1 Location: Chr11:69871994-69881427 bp, + strand Genetic Position: Chr11, 42.95 cM, cytoband B4
• Alliance: Ctdnep1^tm2Ryn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199855
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: The targeted construct replaced the coding sequence in exon 1 through exon 4 with a lox71 site, lacZ reporter gene, polyadenylation sequence, FRT site, neomycin resistance cassette, FRT site, loxP site and polyadenylation sequence. Q-PCR confirmed the absence of transcript expression in E7.5 embryos. (J:199855)

Generation of the Ctdnep1^tm2Ryn allele

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctdnep1 Mutation: 20 strains or lines available

References

• Original: J:199855 Tanaka SS, et al., Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428
• All: 3 reference(s)