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Ctdnep1tm2Ryn
Targeted Allele Detail
Summary
Symbol: Ctdnep1tm2Ryn
Name: CTD nuclear envelope phosphatase 1; targeted mutation 2, Ryuichi Nishinakamura
MGI ID: MGI:5510831
Synonyms: DullardLacZ
Gene: Ctdnep1  Location: Chr11:69871994-69881427 bp, + strand  Genetic Position: Chr11, 42.95 cM, cytoband B4
Alliance: Ctdnep1tm2Ryn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199855
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeted construct replaced the coding sequence in exon 1 through exon 4 with a lox71 site, lacZ reporter gene, polyadenylation sequence, FRT site, neomycin resistance cassette, FRT site, loxP site and polyadenylation sequence. Q-PCR confirmed the absence of transcript expression in E7.5 embryos. (J:199855)
Generation of the Ctdnep1tm2Ryn allele
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: C57BL/6NCrlj * CBA/JNCrlj
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
cellular
abnormal primordial germ cell morphology
decreased primordial germ cell number
embryo
abnormal embryonic tissue morphology
abnormal head fold morphology
absent allantois
absent amnion
abnormal extraembryonic coelom morphology
abnormal parietal endoderm morphology
abnormal extraembryonic mesoderm development
mortality/aging
embryonic lethality during organogenesis, complete penetrance
embryonic lethality between somite formation and embryo turning, incomplete penetrance
reproductive system
abnormal primordial germ cell morphology
decreased primordial germ cell number
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctdnep1 Mutation:  20 strains or lines available
References
Original:  J:199855 Tanaka SS, et al., Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

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