Ctdnep1tm2Ryn
Targeted Allele Detail
|
Symbol: |
Ctdnep1tm2Ryn |
Name: |
CTD nuclear envelope phosphatase 1; targeted mutation 2, Ryuichi Nishinakamura |
MGI ID: |
MGI:5510831 |
Synonyms: |
DullardLacZ |
Gene: |
Ctdnep1 Location: Chr11:69871994-69881427 bp, + strand Genetic Position: Chr11, 42.95 cM, cytoband B4
|
Alliance: |
Ctdnep1tm2Ryn page
|
|
|
Allele Type: |
|
Targeted (Null/knockout, Reporter) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: The targeted construct replaced the coding sequence in exon 1 through exon 4 with a lox71 site, lacZ reporter gene, polyadenylation sequence, FRT site, neomycin resistance cassette, FRT site, loxP site and polyadenylation sequence. Q-PCR confirmed the absence of transcript expression in E7.5 embryos.
(J:199855)
|
|
Generation of the Ctdnep1tm2Ryn allele |
|
|
Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
|
Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
---|
Loading... | | | involves: C57BL/6NCrlj * CBA/JNCrlj | |
|
Phenotypes: |
Affected Systems |
|
|
cellular
|
√
|
abnormal primordial germ cell morphology
|
√
|
decreased primordial germ cell number
|
√
|
embryo
|
√
|
abnormal embryonic tissue morphology
|
√
|
abnormal head fold morphology
|
√
|
absent allantois
|
√
|
absent amnion
|
√
|
abnormal extraembryonic coelom morphology
|
√
|
abnormal parietal endoderm morphology
|
√
|
abnormal extraembryonic mesoderm development
|
√
|
mortality/aging
|
√
|
embryonic lethality during organogenesis, complete penetrance
|
√
|
embryonic lethality between somite formation and embryo turning, incomplete penetrance
|
√
|
reproductive system
|
√
|
abnormal primordial germ cell morphology
|
√
|
decreased primordial germ cell number
|
√
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Original: |
J:199855 Tanaka SS, et al., Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428 |
All: |
3 reference(s) |
|