Bpifa1^m1Ingm
Chemically induced Allele Detail

Summary

• Symbol: Bpifa1^m1Ingm
• Name: BPI fold containing family A, member 1; mutation 1, Ingenium Pharmaceuticals
• MGI ID: MGI:5510863
• Synonyms: Splunc1^L50X
• Gene: Bpifa1 Location: Chr2:153984800-153991137 bp, + strand Genetic Position: Chr2, 76.15 cM
• Alliance: Bpifa1^m1Ingm page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion in exon 2. This resuled in a leucine to stop codon change in codon 50 (L50X). mRNA levels detected by RT-PCR were significantly reduced in all tissues tested and protein was absent from lungs and tracheal homogenates. (J:195535)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bpifa1 Mutation: 24 strains or lines available

References

• Original: J:195535 Liu Y, et al., SPLUNC1/BPIFA1 Contributes to Pulmonary Host Defense against Klebsiella pneumoniae Respiratory Infection. Am J Pathol. 2013 May;182(5):1519-31
• All: 5 reference(s)