Rtn4r^tm2.1Stmr
Targeted Allele Detail

Summary

• Symbol: Rtn4r^tm2.1Stmr
• Name: reticulon 4 receptor; targeted mutation 2.1, Stephen M Strittmatter
• MGI ID: MGI:5510951
• Synonyms: ngr1^flox
• Gene: Rtn4r Location: Chr16:17945506-17970272 bp, + strand Genetic Position: Chr16, 11.23 cM, cytoband B1
• Alliance: Rtn4r^tm2.1Stmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201118
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site and a EGFP with a splice acceptor was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:201118)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtn4r Mutation: 24 strains or lines available

References

• Original: J:201118 Wang X, et al., Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 2011 Nov;70(5):805-21
• All: 9 reference(s)