Lbh^tm1.2Kbri
Targeted Allele Detail

Summary

• Symbol: Lbh^tm1.2Kbri
• Name: limb-bud and heart; targeted mutation 1.2, Karoline J Briegel
• MGI ID: MGI:5511022
• Synonyms: Lbh^delta2
• Gene: Lbh Location: Chr17:73225300-73248941 bp, + strand Genetic Position: Chr17, 44.73 cM, cytoband E2
• Alliance: Lbh^tm1.2Kbri page

Postnatal mammary gland defects in Lbh^tm1.2Kbri/Lbh^tm1.2Kbri mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199325
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in embryos. (J:199325)

Generation of the Lbh^tm1.1Kbri and Lbh^tm1.2Kbri alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lbh Mutation: 9 strains or lines available

References

• Original: J:199325 Lindley LE, et al., Generation of mice with a conditional Lbh null allele. Genesis. 2013 Jul;51(7):491-7
• All: 3 reference(s)