Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, TaconicArtemis
• MGI ID: MGI:5512655
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence, RMCE-ready)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir193a (MGI:2676857)

• Mutation details: RMCE introduced into the locus a tetracycline responsive promoter driving inducible expression of the short hairpin encoding Mir193 followed by a codon optimized tetracycline repressor. (J:197989)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:197989 Gebeshuber CA, et al., Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat Med. 2013 Apr;19(4):481-7
• All: 2 reference(s)