Wt1^tm1.1Ceng
Targeted Allele Detail

Summary

• Symbol: Wt1^tm1.1Ceng
• Name: WT1 transcription factor; targeted mutation 1.1, Christoph Englert
• MGI ID: MGI:5512658
• Synonyms: Wt1^flox
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^tm1.1Ceng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by loxP sites. Flp-mediated recombination removed the neomycin resistance cassette inserted downstream of exon 3. (J:197989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:197989 Gebeshuber CA, et al., Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat Med. 2013 Apr;19(4):481-7
• All: 7 reference(s)