Cntfr^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Cntfr^tm1.1Lex
• Name: ciliary neurotrophic factor receptor; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:5512674
• Gene: Cntfr Location: Chr4:41657498-41697089 bp, - strand Genetic Position: Chr4, 21.81 cM
• Alliance: Cntfr^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137159
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-5 of the CNTFRalpha gene (exon 1 contains the start codon) were flanked by loxP sites (floxed). Cre-mediated recombination removed exons 3 through 5. (J:137159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cntfr Mutation: 53 strains or lines available

References

• Original: J:137159 Lee N, et al., Conditional, genetic disruption of ciliary neurotrophic factor receptors reveals a role in adult motor neuron survival. Eur J Neurosci. 2008 Jun;27(11):2830-7
• All: 3 reference(s)