Braf^tm2.1Urr
Targeted Allele Detail

Summary

• Symbol: Braf^tm2.1Urr
• Name: Braf transforming gene; targeted mutation 2.1, Urr R Rapp
• MGI ID: MGI:5512688
• Synonyms: BRaf^fl
• Gene: Braf Location: Chr6:39580171-39702397 bp, - strand Genetic Position: Chr6, 18.43 cM
• Alliance: Braf^tm2.1Urr page

Cerebellar abnormalities in Braf^tm2Urr/Braf^tm2Urr Tg(Nes-cre)1Kln/0 and Braf^tm2.1Urr/Braf^tm2.1Urr Tg(Nes-cre)1Kln/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:199842)

Generation of the Braf^tm2Urr, Braf^tm2.1Urr, and Braf^tm2.2Urr alleles

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Braf Mutation: 60 strains or lines available

References

• Original: J:199842 Pfeiffer V, et al., Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum. PLoS One. 2013;8(3):e58259
• All: 2 reference(s)