Tg(tetO-SNCA)0Olri
Transgene Detail

Summary

• Symbol: Tg(tetO-SNCA)0Olri
• Name: transgene insertion 0, Olaf Riess
• MGI ID: MGI:5512701
• Synonyms: alpha-syn
• Transgene: Tg(tetO-SNCA)0Olri Location: unknown
• Alliance: Tg(tetO-SNCA)0Olri page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-SNCA)0Olri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: This transgene consists of the human alpha-synuclein cDNA (nucleotides 46-520) downstream of the tet-responsive element. Two lines were made: alpha-syn and alpha-syn1. This line is the one referred to as alpha-syn. (J:132774)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:132774 Nuber S, et al., Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J Neurosci. 2008 Mar 5;28(10):2471-84
• All: 2 reference(s)