Mpig6b^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Mpig6b^tm1.1Arte
• Name: megakaryocyte and platelet inhibitory receptor G6b; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5512767
• Synonyms: G6b^fl
• Gene: Mpig6b Location: Chr17:35281669-35285160 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Mpig6b^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201266
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 6. Cre-mediated recombination removed exons 1 through 6. (J:201266)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpig6b Mutation: 8 strains or lines available

References

• Original: J:201266 Mazharian A, et al., Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Sci Signal. 2012;5(248):ra78
• All: 3 reference(s)