Tg(CAG-Lyn*)#Paau
Transgene Detail

Summary

• Symbol: Tg(CAG-Lyn*)#Paau
• Name: transgene insertion, Patrick Auberger
• MGI ID: MGI:5512882
• Synonyms: LynDeltaN
• Transgene: Tg(CAG-Lyn*)#Paau Location: unknown
• Alliance: Tg(CAG-Lyn*)#Paau page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Lyn*)#Paau expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Lyn

• Mutation details: This transgene consists of the cytomegalovirus enhancer, the chicken beta-actin promoter, the caspase-cleaved form of Lyn, and a rabbit beta-globin polyadenylic acid sequence. Four lines were developed. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:151886)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tg(CAG-Lyn*)#Paau/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6 * DBA/2
cx2	Rag1^tm1Mom/Rag1^tm1Mom Tg(CAG-Lyn*)#Paau/0	involves: 129S7/SvEvBrd * C57BL/6
tg3  Disease Model	Tg(CAG-Lyn*)#Paau/0	B6.Cg-Tg(CAG-Lyn*)#Paau

Phenotypes:

Affected Systems	cx1	cx2	tg3
show or hide all annotated terms
behavior/neurological			√
decreased food intake			√
cellular			√
increased keratinocyte proliferation			√
growth/size/body			√
decreased body size			√
homeostasis/metabolism			√
extremity edema			√
epidermal spongiosis			√
immune system		√	√
decreased inflammatory response		√
skin inflammation			√
integument	N		√
integument phenotype	N
increased keratinocyte proliferation			√
epidermal spongiosis			√
skin inflammation			√
hyperkeratosis			√
parakeratosis			√
thin epidermis stratum granulosum			√
acanthosis			√
reddish skin			√
scaly skin			√
skin lesions			√
psoriasis			√
thick skin			√
mortality/aging			√
postnatal lethality, incomplete penetrance			√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg3
psoriasis IDs psoriasis       DOID:8893 EFO:0000676 ICD10CM:L40 MESH:D011565 NCI:C3346 OMIM:PS177900 UMLS_CUI:C0033860 Close	√

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:151886 Marchetti S, et al., The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice. EMBO J. 2009 Aug 19;28(16):2449-60
• All: 2 reference(s)