Sox2^{tm1.1(cre/ERT2)Jpmb}
Targeted Allele Detail

Summary

• Symbol: Sox2^{tm1.1(cre/ERT2)Jpmb}
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Juan Pedro Martinez Barbera
• MGI ID: MGI:5512893
• Synonyms: Sox2^CreERT2, Sox2^{tm1.1(cre)Jpmb}
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^{tm1.1(cre/ERT2)Jpmb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201265
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sox2^{tm1.1(cre/ERT2)Jpmb} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox2 (MGI:98364)

• Mutation details: Homologous recombination in ES cells inserted a cre/ERT2-PGK-neo cassette into the Sox2 locus, generating a knockin allele that functionally is a null allele of Sox2. The frt-flanked neo marker was deleted by crossing animals with Tg(ACTFLPe)9205Dym mice. Lineage tracing in embryos from tamoxifen treated females of R26^YFP and Sox2^Cre/ERT2 intercrosses demonstrated labelled cells at P1 in tissues that normally express Sox2 (brain, eyes, ears, oral epithelia). (J:201265)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:201265 Andoniadou CL, et al., Sox2 Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential. Cell Stem Cell. 2013 Oct 3;13(4):433-445
• All: 13 reference(s)