Klra5^tm1.2Glec
Targeted Allele Detail

Summary

• Symbol: Klra5^tm1.2Glec
• Name: killer cell lectin-like receptor, subfamily A, member 5; targeted mutation 1.2, Georges Leclercq
• MGI ID: MGI:5512899
• Synonyms: Ly49E^KO
• Gene: Klra5 Location: Chr6:129874715-129890188 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Klra5^tm1.2Glec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201231
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 and 3 floxed. Cre-mediated recombination removed exons 2 and 3. FACS analysis confirmed the absence of protein expression in cells from fetal day 17 spleen and thymus and adult bone marrow and spleen. (J:201231)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klra5 Mutation: 34 strains or lines available

References

• Original: J:201231 Filtjens J, et al., Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function. J Leukoc Biol. 2013 May;93(5):699-711
• All: 5 reference(s)